Table 3.
Subgroup analyses of percentages of patients still positive for viral RNA at day 5 of treatment in samples taken from throat. Patients were grouped according to age, detected virus, and day of illness on enrolment
| Standard dose | Double dose | P value‡ | ||||||
|---|---|---|---|---|---|---|---|---|
| No* (%) | Copy number (range)† | No with positive quantitative RT-PCR result | No* (%) | Copy number (range)† | No with positive quantitative RT-PCR result | |||
| Age groups | ||||||||
| All | 33/143 (23.1) | 3.85e+03 (1.00e+03-3.01e+05) | 11 | 29/151 (19.2) | 1.83e+04 (1.00e+03-4.07e+05) | 14 | 0.40 | |
| <18 | 29/116 (25) | 4.12e+03 (1.00e+03-3.01e+05) | 10 | 23/119 (19.3) | 1.86e+04 (1.16e+03-1.45e+05) | 11 | 0.30 | |
| 0-4 | 25/105 (23.8) | 4.12e+03 (1.00e+03-3.01e+05) | 10 | 22/106 (20.8) | 1.95e+04 (2.06e+03-1.45e+05) | 10 | 0.60 | |
| 5-17 | 4/11 (36.4) | — | 0 | 1/13 (7.7) | 1.16e+03 (1.16e+03−1.16e+03) | 1 | 0.08 | |
| ≥18 | 4/27 (14.8) | 1.00e+03 (1.00e+03-1.00e+03) | 1 | 6/32(18.8) | 1.00e+03 (1.00e+03-4.07e+05) | 3 | 0.73 | |
| 18-59 | 2/17 (11.8) | 1.00e+03 (1.00e+03-1.00e+03) | 1 | 5/27 (16.7) | 2.04e+05 (1.00e+03-4.07e+05) | 1 | 0.68 | |
| ≥60 | 2/10 (20) | — | 0 | 1/2 (50) | 1.00e+03 (1.00e+03-1.00e+03) | ‘1 | 0.37 | |
| Virus type | ||||||||
| 1977 H1N1 | 4/23 (17.4) | 4.39e+03 (4.39e+03-4.39e+03) | 1 | 3/12 (25) | 1.79e+04 (1.21e+04-1.13e+05) | 3 | 0.59 | |
| H3N2 | 17/60 (28.3) | 3.85e+03 (2.08e+03-3.01e+05) | 5 | 15/71 (21.1) | 1.05e+04 (1.16e+03−1.45e+05) | 6 | 0.34 | |
| H1N1-pdm09 | 4/34 (11.8) | 1.00e+03 (1.00e+03-1.00e+03) | 1 | 3/37 (8.1) | — | 0 | 0.61 | |
| H5N1 | 0/0 (0) | — | 0 | 2/4 (50) | 2.04e+05 (1.00e+03-4.07e+05) | 2 | ||
| B | 8/26 (30.8) | 4.58e+03 (1.00e+03-2.86e+04) | 4 | 6/27 (22.2) | 2.03e+04 (1.00e+03-3.44e+04) | 3 | 0.48 | |
| Time to treatment (days from onset of illness) | ||||||||
| Within 2 | 5/17 (29.4) | 3.57e+03 (2.74e+03-4.39e+03) | 2 | 7/14 (50) | 2.39e+03 (1.00e+03-1.45e+05) | 5 | 0.24 | |
| Within 3 | 7/37 (18.9) | 3.57e+03 (2.74e+03−-4.39e+03) | 2 | 10/33 (30.3) | 1.01e+04 (1.00e+03-1.45e+05) | 8 | 0.27 | |
| Within 4 | 14/63 (22.2) | 2.41e+03 (1.00e+03-8.16e+03) | 6 | 15/61 (24.6) | 1.83e+04 (1.00e+03-1.45e+05) | 10 | 0.76 | |
| >4 | 19/80 (23.8) | 1.59e+04 (1.00e+03-3.01e+05) | 5 | 12/86 (14) | 1.21e+04 (1.00e+03-4.07e+05) | 3 | ||
RT-PCR=reverse transcriptase polymerase chain reaction.
*Patients still positive by qualitative RT-PCR in each arm per subgroup.
†Calculated from results of quantitative RT-PCR.
‡From χ2 for comparison of number of patients still positive by qualitative RT-PCR in each arm.