Table 1.

Experimental conditions for studies on the role of the CRF system in social defeat stress.

Study	Species (strain)	Sex	Housing	Control condition	Duration of stressor	Measure/manipulation	Site/route
EFFECTS OF SOCIAL DEFEAT STRESS ON CENTRAL CRF SYSTEM
Funk et al., 2006	Rat (Wistar)	Male	Not spec.	No stress	30 min	CRF mRNA (in situ)
Panksepp et al., 2007	Rat (Long–Evans)	Male	Group	Novel non-aggressive	30 min	CRF-like peptide (RIA)
Fekete et al., 2009	Rat (Wistar)	Male	Single	Handling only	75 min	CRF R2 mRNA in situ and c-fos ICC
PHARMACOLOGICAL EFFECTS ON THE EXPRESSION AND ACQUISITION OF CONDITIONED DEFEAT STRESS
Robison et al., 2004	Mice (C57BL/6)	Not spec.	Single	Antalarmin, non-stress	10 min	Antalarmin	BLA
Jasnow et al., 1999	Syrian hamsters	Male	Single	None	4 × 5 min over 1 day	CP-154,526	i.p.
	Syrian hamsters	Male	Single	None	4 × 5 min over 1 day	D-Phe CRF	i.c.v.
Jasnow et al., 2004	Syrian hamsters	Male	Single	None	15 min	D-Phe CRF	BNST
	Syrian hamsters	Male	Single	None	15 min	D-Phe CRF	CeA
Cooper and Huhman, 2005	Syrian hamsters	Male	Single	Empty resident cage	15 min	anti-SVG-30	i.c.v.
	Syrian hamsters	Male	Single	Empty resident cage	15 min	CP-154,526	i.c.v.
	Syrian hamsters	Male	Single	Empty resident cage	15 min	anti-SVG-30	BNST
Cooper and Huhman, 2007	Syrian hamsters	Male	Single	Empty resident cage	15 min	D-Phe CRF	DRN
	Syrian hamsters	Male	Single	Empty resident cage	15 min	anti-SVG-30	DRN
	Syrian hamsters	Male	Single	Empty resident cage	15 min	D-Phe CRF	DRN
	Syrian hamsters	Male	Single	Empty resident cage	15 min	anti-SVG-30	DRN
Cooper and Huhman, 2010	Syrian hamsters	Male	Single	None	15 min	D-Phe CRF	i.c.v.
	Syrian hamsters	Male	Single	None	15 min	anti-SVG-30	i.c.v.
	Syrian hamsters	Male	Single	None	15 min	CP-154,526	i.c.v.
PHARMACOLOGICAL EFFECTS ON OTHER BEHAVIORAL CONSEQUENCES OF SOCIAL DEFEAT STRESS
Heinrichs et al., 1992	Rat (Wistar)	Male	Not spec.	No stress	30 min	α-helical CRF	i.c.v.
	Rat (Wistar)	Male	Not spec.	No stress	30 min	α-helical CRF	CeA
Liebsch et al., 1995	Rat (Wistar)	Male	SINGLE	None	10 min	Antisense oligonucleotide	CeA
Wood et al., 2012	Rat (Sprague Dawley)	Male	SINGLE	Novel cage	30 min × 7 days	NBI-30775	s.c.
Wang et al., 2011	Mice	Male	SINGLE	No stress	24 h × 21 days	CRH R1 deficiency	Forebrain

Housing indicates how animals were housed prior to any SDS testing (“not spec.” indicates that pre-testing housing was not indicated, and is presumed to be isolation). Control condition refers specifically to any behavioral controls (“none” indicates all animals were tested for response to stress).