Table 1.
Effects of CNX-011-67 on blood HbA1c, Fructosamine, PDX1 and apoptotic positive cells
| Parameters | |
Groupings |
|
|---|---|---|---|
| Lean control | ZDF control | CNX-011-67 (5 mg/kg) | |
| HbA1c |
3.84 ± 0.08 |
5.50 ± 0.30 |
5.18 ± 0.11 |
| Fructosamine |
92.47 ± 10.68 |
236.36 ± 19.08 |
111.25 ± 10.61** |
| HOMA-IR |
2.16 ± 0.74 |
64.26 ± 6.18 |
41.82 ± 2.59* |
| HOMA-beta |
117.34 ± 39.35 |
1520.20 ± 227.30 |
2206.79 ± 418.69 |
| PDX1 positive cells |
650 ± 49 |
461 ± 47.50 |
589 ± 43 |
| Apoptotic cells | 00 ± 00 | 47 ± 8.7 | 29 ± 4.6 |
Data in all panels are mean ± SEM (n = 10/group). Statistical comparison was conducted by One-way ANOVA with Dunnett’s post test correction to arrive at the significance level when compared with ZDF control. (*p < 0.05 and **p < 0.01).