Table 2.
Agents tested by the PPTP with low activity (L) in osteosarcoma xenografts and corresponding clinical trials that include pediatric patients with osteosarcoma.
| Target | Agent | Reference | Response activity | Clinicaltrial.gov identifier |
|---|---|---|---|---|
| Bcl-2/Bcl-XL | ABT-263 | Lock et al. (2008) | L | – |
| EGFR | Lapatinib | Gorlick et al. (2009) | L | NCT01454804 |
| HSP90 | AT13387 | Kang et al. (2012) | L | – |
| HSP90 | Alvespimycin | Smith et al. (2008) | L | – |
| Immune system | Lenalidomide | Reynolds et al. (2011) | L | – |
| MDM2 | RG7112 | Carol et al. (2013) | L | – |
| NEDD8-activating enzyme | MLN4924 | Smith et al. (2012b) | L | – |
| PIMI kinase | SGI-1776 | Batra et al. (2012) | L | – |
| Proteosome | Bortezomib | Houghton et al. (2008b) | L | NCT00994500 |
| y-Secretase | RO4929097 | Kolb et al. (2012a) | L | – |
| Unknown | Seneca valley virus | Morton et al. (2010) | L | – |
L, low activity.