Figure 2.

The “triangle” method for integration of genotype, gene expression, and phenotype data. Through a series of steps, heterogeneous datasets, involving SNPs, gene expression and trait are integrated. At each step, a p-value threshold is applied. In general, the p-value threshold used is arbitrary; in practice, the choice allows for prioritization of genes or SNPs. The result of the triangle method is a set of SNP association p-values (represented by the “obs p” in the figure).