Table 1.

Pentraxin 3 interacts with various ligands to mediate diverse function.

	Ligand	Role	Characteristics of interaction	Reference
1	P-selectin	Inhibition of neutrophil migration	C-terminal domain is required	Deban et al. (2010)
			Dependent on glycosylation pattern
2	C1q	Complement activation	C-terminal domain of PTX3 is required	Inforzato et al. (2006), Baruah et al. (2006)
			Desialylation of PTX3 favors interaction
			Interaction is mediated through globular head of C1q
			Inhibitory effect when C1q is in fluid phase
			Calcium independent
3	Ficolins	Complement activation	Calcium dependent	Ma et al. (2009), Gout et al. (2011)
			Interaction mediates through fibrinogen-like domain of ficolins
			Glycosylation pattern in C-terminal domain of PTX3 is a determining factor
4	Factor H	Complement activation	N- and C-terminal domains are required for interaction	Deban et al. (2008)
			Interaction is calcium dependent
			Glycosylation of PTX3 stabilizes the interaction
5	MBL	Complement activation	Mediated through collagen like domain of MBL	Martin et al. (2009)
			Interaction dependent on calcium
6	FyRs	Opsonophagocytosis		Moalli et al. (2010), Lu et al. (2008)
7	FGF-2/8b	Anti-angiogenesis	Interaction through N-terminal domain (FGF-2)	Moalli et al. (2010), Lu et al. (2008), Rusnati et al. (2004), Camozzi et al. (2005, 2006)
8	TSG-6	Extracellular matrix deposition	Interaction through N-terminal domain	Salustri et al. (2004), Maina et al. (2009)
9	Galactomannan (component of conidia)	Disposal of conidia		Garlanda et al. (2002)
10	OmpA (Klebsiella pneumoniae)	Activation of immune response against Klebsiella (complement activation)	High affinity interaction Calcium dependent	Cotena et al. (2007), Jeannin et al. (2005)
11	Hemagglutinin	Inhibition of viral attachment to host cells	Calcium independent Sialic moiety on PTX3 and mannose on hemagglutinin are involved in interaction	Bozza et al. (2006), Reading et al. (2008)

This table shows list of PTX3 ligands and role and characteristic features of their interaction.