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. Author manuscript; available in PMC: 2013 May 31.
Published in final edited form as: J Biol Chem. 2006 Mar 29;281(22):15258–15267. doi: 10.1074/jbc.M512953200

FIGURE 8. jnk2−/− mice are protected from GalN/TNF-induced liver injury.

FIGURE 8

A, serum ALT levels from wild-type (WT) and jnk2−/− mice at 6 h after GalN/TNF treatment (*, p < 0.04 as compared with wild type). B, graded histological scoring of the degree of apoptosis (Apop) and inflammation (Inflam) in the same livers (p < 0.01 (*) and p < 0.02 (#) compared with wild type). C, numbers of TUNEL positive cells per high power field in the identical liver sections (*, p < 0.002 compared with wild-type mice). D, immunoblots of total protein isolated from the livers of wild-type (+/+) and jnk2 knock-out (−/−) mice that were untreated or treated with GalN/TNF for 6 h. Samples were immunoblotted with antibodies against caspase-8, -3, and -7, PARP, and β-actin. The top two panels represent different exposures of the same caspase-8 immunoblot. Results are from three independent experiments with three-five animals per data point.