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Hepatic JNK activity was determined in wild-type (+/+) and jnk1 (A) or jnk2 (B) knock-out (−/−) mice that were untreated or treated with GalN/LPS for the number of hours shown. JNK activity is reflected in the levels of phosphorylated c-Jun (P-c-Jun) on immunoblots. Stripped membranes were immunoblotted for total c-Jun to indicate equal protein loading.
