Table 2.
Demographic and Metabolic Characteristics of Ashkenazi Offspring and Controls Categorized by MTP Genotype
| Trait | CC, n = 113 | CG/GG, n = 320 | p Value, CC vs CG/GG | |
| * | † | |||
| Female (%) | 51 | 59 | .15 | .14 |
| Age, y | 70.2 ± 0.8 | 73.1 ± 0.5 | .004 | .004 |
| Age range, y | 44–92 | 49–93 | ||
| Glucose, mg/dL | 90 ± 4 | 95 ± 2 | .25 | .26 |
| Insulin, mg/dL | 19.2 ± 3.2 | 20.8 ± 2.3 | .68 | .33 |
| CRP | 0.39 ± 0.07 | 0.37 ± 0.04 | .73 | .53 |
| Cholesterol, mg/dL | 204 ± 4 | 203 ± 2 | .78 | .61 |
| Apo-A1, mg/dL | 154 ± 3 | 157 ± 2 | .45 | .42 |
| Apo-B, mg/dL | 105 ± 3 | 102 ± 2 | .37 | .40 |
| VLDL particle size, nm | 48.9 ± 1.7 | 47.6 ± 0.8 | .45 | .54 |
| LDL, mg/dL | 117 ± 4 | 116 ± 2 | .85 | .54 |
| LDL1, mg/dL | 67.2 ± 5.6 | 71.4 ± 2.9 | .47 | .72 |
| LDL3, mg/dL | 32.8 ± 4.2 | 28.2 ± 2.3 | .3 | .46 |
| LDL particle size, nm | 20.9 ± 0.1 | 21.0 ± 0.1 | .34 | .77 |
| HDL, mg/dL | 59.5 ± 1.7 | 60.8 ± 1.1 | .53 | .4 |
| Large HDL, mg/dL | 28.8 ± 2.1 | 32.1 ± 1.2 | .17 | .72 |
| Small HDL, mg/dL | 18.2 ± 0.7 | 17.5 ± 0.5 | .66 | .92 |
| HDL particle size, nm | 9.06 ± 0.05 | 9.16 ± 0.03 | .15 | .48 |
Notes: Data are expressed as means ± SE. Crude means are shown. TG, which were not normally distributed, were log-transformed for analysis but presented as untransformed raw values. HDL = high-density lipoprotein; LDL = low-density lipoprotein; VLDL = very low-density lipoproteins.
p Values between CC carriers and CG/GG carriers unadjusted.
p Values between CC carriers and CG/GG carriers adjusted for age and sex (glucose [mg/dL], insulin [mg/dL], CRP, cholesterol [mg/dL], triglycerides [mg/dL], Apo-A1 [mg/dL], ApoB [mg/dL], VLDL particle size [nm], LDL [total levels, 1 and 3; mg/dL], LDL particle size [nm], HDL [total levels, large, and small; mg/dL], HDL particle size [nm]).