Table 3. Treatment differences in the 15 individual FKSI-15 items.
| Estimated mean | |||||
|---|---|---|---|---|---|
| Item | Axitinib (n=361) | Sorafenib (n=362) | Difference | 95% CI | P-value |
| 1. I have a lack of energy |
1.52 |
1.50 |
0.03 |
−0.09, 0.15 |
0.6627 |
| 2. I am bothered by side effects of treatment |
1.43 |
1.53 |
−0.11 |
−0.25, 0.04 |
0.1399 |
| 3. I have pain |
1.14 |
1.19 |
−0.05 |
−0.18, 0.08 |
0.4752 |
| 4. I am losing weight |
0.81 |
0.83 |
−0.02 |
−0.14, 0.10 |
0.7724 |
| 5. I have bone pain |
0.75 |
0.72 |
0.03 |
−0.10, 0.15 |
0.6782 |
| 6. I feel fatigued |
1.44 |
1.43 |
0.01 |
−0.11, 0.13 |
0.9157 |
| 7. I am able to enjoy life |
2.27 |
2.39 |
−0.12 |
−0.25, 0.02 |
0.0925 |
| 8. I have been short of breath |
0.87 |
0.88 |
−0.01 |
−0.11, 0.10 |
0.9219 |
| 9. I worry that my condition will get worse |
1.44 |
1.55 |
−0.11 |
−0.24, 0.02 |
0.0918 |
| 10. I have a good appetite |
2.05 |
2.09 |
−0.04 |
0.18, 0.11 |
0.6078 |
| 11. I have been coughing |
0.71 |
0.71 |
0.00 |
−0.11, 0.10 |
0.9354 |
| 12. I am bothered by fever |
0.13 |
0.15 |
−0.02 |
−0.07, 0.04 |
0.5989 |
| 13. I am able to work (includes work from home) |
1.92 |
1.92 |
−0.01 |
−0.15, 0.14 |
0.9391 |
| 14. I have blood in my urine |
0.03 |
0.04 |
−0.02 |
−0.04, 0.00 |
0.1369 |
| 15. I am sleeping well | 2.36 | 2.29 | 0.06 | −0.07, 0.19 | 0.3543 |
Abbreviations: CI=confidence interval; FKSI-DRS=Functional Assessment of Cancer Therapy–Kidney Cancer Symptom Index-disease-related symptoms subscale; FKSI-15=Functional Assessment of Cancer Therapy Kidney Symptom Index-15.
Analysis based on repeated measures mixed-effects model with terms for treatment, time, and treatment-by-time, with baseline as covariate and time assumed continuous. Means are based on observed scores 0–4, where 0=not at all, 1=a little bit, 2=somewhat, 3=quite a bit, and 4=very much. A larger score may correspond to a better or worse health state depending on the item question. FKSI-DRS consists of questions 1, 3, 4, 5, 6, 8, 11, 12, and 14 of the FKSI-15.