Table 3. Univariate and multivariate analysis of association of prognostic factors and N/L ratio with time to tumour recurrence.
| |
Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| Parameter | HR (95% CI) | P-value | HR (95% CI) | P-value |
|
Sex | ||||
| Female | 1 (referent) | 0.593 | 1 (referent) | 0.924 |
| Male |
1.165 (0.66–2.04) |
|
1.03 (0.57–1.85) |
|
|
Tumour site | ||||
| Extremities | 1 (referent) | 0.827 | 1 (referent) | 0.400 |
| Trunk |
1.093 (0.49–2.43) |
|
1.42 (0.63–3.20) |
|
|
Tumour depth | ||||
| Superficial | 1 (referent) | 0.987 | 1 (referent) | 0.636 |
| Deep |
1.01 (0.52–1.94) |
|
0.85 (0.44–1.66) |
|
|
Tumour grade | ||||
| G1 | 1 (referent) | 0.040 | 1 (referent) | 0.156 |
| G2 | 0.16 (0.04–0.67) | 3.81 (0.80–18.11) | ||
| G3 |
1.00 (0.54–1.88) |
|
2.37 (0.51–11.02) |
|
|
Tumour size | ||||
| <5 cm | 1 (referent) | 0.169 | 1 (referent) | 0.322 |
| ⩾5 cm |
1.67 (0.81–3.50) |
|
1.47 (0.69–3.12) |
|
|
Tumour necrosis | ||||
| 0 | 1 (referent) | 0.001 | 1 (referent) | 0.037 |
| ⩽50% | 2.67 (1.32–5.41) | 1.96 (0.95–4.04) | ||
| >50% |
3.99 (1.88–8.46) |
|
3.00 (1.28–7.01) |
|
|
Resection margins | ||||
| Wide | 1 (referent) | 0.971 | 1 (referent) | 0.637 |
| Marginal |
1.02 (0.37–2.83) |
|
1.29 (0.44–3.78) |
|
|
Tumour stage | ||||
| Localised at diagnosis | NA | NA | NA | NA |
| Metastasised at diagnosis |
|
|
|
|
|
Adjuvant chemotherapy | ||||
| Yes | 1 (referent) | <0.001 | 1 (referent) | 0.005 |
| No |
3.01 (1.69–5.39) |
|
1.16 (0.55–2.44) |
|
|
Adjuvant radiotherapy | ||||
| Yes | 1 (referent) | 0.047 | 1 (referent) | 0.692 |
| No |
1.97 (1.01–3.86) |
|
1.16 (0.55–2.44) |
|
|
N/L ratio 3.45 | ||||
| <3.45 | 1 (referent) | 0.005 | 1 (referent) | 0.035 |
| ⩾3.45 | 2.32 (1.30–4.14) | 1.98 (1.05–3.71) | ||
Abbreviations: CI=confidence interval; HR=hazard ratio; NA=not applicable; N/L=neutrophil/lymphocyte.