Table 2. Correlation of absolute median biomarker levels (Tx) and marker kinetics (Tx−T0%) with objective response to chemotherapy (n=68).
| |
|
PD |
Non-progressive disease (CR+PR+SD) |
P-value |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Marker | Time (days) | n | Tx | Tx−T0% | n | Tx | Tx−T0% | Tx | Tx−T0% |
|
CYFRA 21-1 (ng ml–1) | |||||||||
| |
0 |
26 |
7.5 |
— |
42 |
2.8 |
— |
0.011 |
— |
| |
7 |
19 |
4.1 |
−31.9 |
41 |
2.8 |
−8.8 |
0.262 |
0.040 |
| |
14 |
17 |
3.8 |
−32.4 |
33 |
1.9 |
−31.6 |
0.017 |
0.728 |
| |
21 |
20 |
5.1 |
−31.6 |
33 |
2.6 |
−40.0 |
0.021 |
0.267 |
| |
28 |
15 |
3.3 |
−43.1 |
30 |
2.1 |
−28.9 |
0.005 |
0.727 |
| |
S |
23 |
4.6 |
−20.8 |
39 |
1.6 |
−39.1 |
<0.001 |
0.311 |
|
CEA (ng ml–1) | |||||||||
| |
0 |
26 |
17.1 |
— |
42 |
3.7 |
— |
0.008 |
— |
| |
7 |
19 |
15.6 |
−12.5 |
41 |
3.2 |
−10.2 |
0.078 |
0.313 |
| |
14 |
17 |
15.4 |
0.0 |
33 |
2.5 |
−22.1 |
0.007 |
0.037 |
| |
21 |
20 |
10.4 |
−6.8 |
33 |
3.1 |
−27.3 |
0.130 |
0.394 |
| |
28 |
15 |
11.4 |
3.3 |
30 |
2.6 |
−26.9 |
0.043 |
0.092 |
| |
S |
23 |
18.1 |
0.0 |
39 |
2.6 |
−26.3 |
0.002 |
0.078 |
|
CA 19-9 (U ml–1) | |||||||||
| |
0 |
24 |
5810.5 |
— |
40 |
341.5 |
— |
0.006 |
— |
| |
7 |
17 |
6487.0 |
−2.4 |
39 |
388.0 |
−10.4 |
0.023 |
0.557 |
| |
14 |
16 |
5590.5 |
−13.8 |
31 |
232.0 |
−32.9 |
0.005 |
0.119 |
| |
21 |
20 |
3657.0 |
−20.2 |
31 |
446.0 |
−31.2 |
0.020 |
0.259 |
| |
28 |
14 |
4177.0 |
−11.5 |
29 |
241.0 |
−42.0 |
0.013 |
0.209 |
| S | 21 | 6428.0 | −17.4 | 37 | 135.0 | −65.2 | <0.001 | <0.001 | |
Abbreviations: CR=complete remission; PD=progressive disease; PR=partial remission; S=staging (=day 56); SD=stable disease; Tx=marker value at a specific time point (x); Tx−T0%=percentage marker decrease or increase based on the difference from baseline (T0), calculated only for patients with data available at the specific time point (n).