Fig. 5.

Surface potential diagram – (A) for ANG and (B, C) for AEH molecule. In (B) the surface charge near the C-terminal region (active site) is similar to ANG, but in (C) the C-terminal region undergoes a conformational change and forms a long groove where the substrate possibly binds. Differences are due to the changes observed in the conformations of the loop regions 1 and 2 for the AEH molecule. (D) An oligomer of DNA backbone (coloured in red) (10-mer, with only phosphate and ribose moieties) docked on to the AEH molecule B. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)