Fig. 4.

Circadian rhythms of core body temperature (T_b) and hepatic Cirbp expression of fasted mice. Mice were fed (unfilled circles) or fasted (filled circles) under 12 h light–12 h dark cycles (LD 12:12; lights on at 0 h). (A) Continuous T_b change during the experiment. (B) Averaged circadian rhythms of T_b under fed and fasted conditions. Data are averaged T_b values during fed (unfilled circles) and fasted (filled circles). Values are shown as means ± SEM (n = 7). (C) Temporal mRNA expression profiles of Cirbp in the liver of fasted mice. Messenger RNA levels were measured by quantitative RT-PCR. Maximal value for fed mice is expressed as 100%. Values are means ± SEM (n = 4). Significant differences between fed and fasted groups are indicated as *P < 0.05, **P < 0.01. Horizontal unfilled and solid bars, day and night, respectively.