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. Author manuscript; available in PMC: 2013 May 31.

Published in final edited form as: Thromb Haemost. 2013 Jan 24;109(4):684–695. doi: 10.1160/TH12-08-0543

Table 1.

MRSA induces a time-dependent (A) and concentration-dependent (B), pro-coagulant response in whole blood.

A	NT	5 h	12 h	24 h
Lag (min)	21.0 ± 1.9	16.3 ± 0.8	6.2 ± 0.6^*	4.7 ± 0.7^*
Peak (nM)	196.8 ± 22.7	279.3 ± 86.4	318.5 ± 9.0	256.1 ± 20.4
Time to Peak (min)	31.3 ± 2.0	28.2 ± 5.4	9.0 ± 1.0^*	6.2 ± 1.1^*
Rate (nM/min)	21.2 ± 4.2	36.6 ± 16.8	118.8 ± 18.0	186.0 ± 45.2^*
AUC (nM^* min)	2999.8 ± 449.8	2762.0 ± 900.3	3162.6 ± 122.1	2579.6 ± 115.7
B	NT	9x10² cfu/ml	9x10⁴ cfu/ml	9x10⁶ cfu/ml
Lag (min)	20.0 ± 0.8	19.0 ± 1.4	6.2 ± 0.6^*	4.0 ± 0.6^*
Peak (nM)	192.2 ± 33.4	159.7 ± 24.3	318.5 ± 9	342.0 ± 34.5
Time to Peak (min)	32.3 ± 0.9	29.8 ± 1.8	9.0 ± 1^*	6.2 ± 0.7^*
Rate (nM/min)	16.8 ± 4.1	15.8 ± 3.6	118.8 ± 18	161.6 ± 17.7^*
AUC (nM^* min)	2379.7 ± 443.6	2241.0 ± 314	3162.6 ± 122.1	3276.8 ± 398.3

^*

p<0.05 vs. NT.