Table 3.

Antibiotics inhibit MRSA-induced thrombin generation.

Time (h)	-		0		6		12
Antibiotic	-		VANC	LZ	VANC	LZ	VANC	LZ
MRSA	−	+	+	+	+	+	+	+
Lag (min)	18.0 ± 1.3	4.3 ± 0.3*	17.0 ± 0.6**	18.0 ± 1.8**	12.7 ± 2.4**	15.0 ± 0.6**	5.7 ± 0.7*	7.0 ± 0.6*
Peak (nM)	269.1 ± 45.2	470.0 ± 39	275.9 ± 27.5	359.0 ± 102.9	305.4 ± 51.6	265.8 ± 9.7	408.6 ± 31.1	382.6 ± 4.6
Time to Peak (min)	30.0 ± 3.3	7.2 ± 0.4*	29.2 ± 1.4**	27.5 ± 4.1**	21.3 ± 4**	24.2 ± 1.7**	10.3 ± 1.6*	11.8 ± 1.3*
Rate (nM/min)	26.0 ± 7.5	178.6 ± 25.3*	25.9 ± 5.5**	57.2 ± 34.4**	43.6 ± 13.3**	28.4 ± 5.3**	93.7 ± 14.3**	83.7 ± 13.3**
AUC (nM* min)	3458.9 ± 516.7	3957.9 ± 456.6	3539.7 ± 413	3816.0 ± 522.3	3767.8 ± 477.8	3599.2 ± 265	4031.2 ± 467.8	3810.7 ± 189.4

^*p<0.05 vs. no MRSA.

^**p<0.05 vs. MRSA alone without antibiotics.