Table 1.

Checklist of items to consider when planning a multisite randomized clinical trial^*

Randomization and Blinding

Are randomization schemes appropriate for the type of trial and the desired outcome?

Are randomization assignments blinded, when appropriate?

Are assessors blinded, when appropriate?

Intervention

Has the intervention and study procedures been standardized across sites?

Are plans in place to ensure that sites are adhering to the standard?

Participant Follow-up

Is participant follow-up standard across sites?

Are plans in place to assess each site’s follow-up rate?

Are plans in place to deal with missing data?

^*Adapted from The Checklist to Evaluate a Report of Non-Pharmacological Trial (CLEAR NPT)