. Author manuscript; available in PMC: 2014 Feb 1.

Published in final edited form as: Drug Deliv Transl Res. 2012 Aug 1;3(1):63–74. doi: 10.1007/s13346-012-0092-0

Table 2.

Biopharmaceutics of intranasal naltrexone, hydromorphone and butorphanol [48, 49]

Drug and Dose	C_{max (ng/mL)}	T_{max (minutes)}	Bioavailability (%)
Naltrexone HC l 10 mg	14.9	22	600 (to oral)
Hydromorphone HCl 2 mg	3.5	20	50-60
Butorphanol tartrate 2 mg	5.5	10	60-70