Table 1.
Baseline characteristics and drinking outcomes [mean +/− S.D.].
| Characteristic | Naltrexone + Sertraline (N=57) |
Naltrexone + Placebo (N=54) |
|---|---|---|
| Age | 41.5 (9.55) | 44.9 (9.68) |
| Male Gender (%) | 80.7 | 83.3 |
| Race or Ethnic group (%): | ||
| White | 71.4 | 71.2 |
| Black | 12.5 | 11.5 |
| Hispanic | 10.7 | 11.5 |
| Other | 5.4 | 5.8 |
| Marital Status: | ||
| % Married or living with partner | 33.9 | 46.2 |
| High school or greater | 91.1 | 90.4 |
| Age of onset of alcohol-related problems | 30.8 (10.09) | 33.3 (8.72) |
| % days abstinent | 29.3 (19.13) | 25.6 (18.66) |
| Drinks per drinking day in previous 90 days | 7.3 (4.82) | 7.4 (4.78) |
| ALT | 7.8 (5.72) | 7.3 (5.30) |
| GGT | 92.7 (122.39) | 118.0 (208.76) |
| Drinking Outcomes (%) | ||
| Drinks per drinking day for drinkers a | 5.3 (4.06) | 4.3 (4.29) |
| Drinks per drinking day for all subjects | 2.8 (3.95) | 3.0 (4.09) |
| Percent days abstinent | 79.2 (30.48) | 84.5 (17.47) |
| OCDS Total b | 7.4 (5.50) | 7.7 (6.23) |
| GGT Change from Baseline | 26.4 (44.70) | 60.5 (170.88) |
| ALT Change from Baseline | 4.0 (33.9) | 10.3 (23.8) |
No significant differences between groups in their baseline characteristics or drinking outcomes.
a
N = 28 for naltrexone + sertraline and N = 37 for naltrexone + placebo.
b
Mixed model.