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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Eur J Immunol. 2012 Aug 6;42(10):2683–2696. doi: 10.1002/eji.201142317

Fig. 3. P4-induced FoxP3 expression is partially dependent on nuclear progesterone receptor.

Fig. 3

(A) Responses of PR (−/−) T cells to P4 in differentiation into iTregs. The culture condition was the same as for Fig. 1D. (B) Frequencies of FoxP3+ T cells in the uterus and other organs of PR (−/−) mice. Data for CD4+CD8− T cells are shown for the thymus. Decreased expression of FoxP3 by CD4+ T cells in the uterus of PR (−/−) mice is shown in the graph. Mean fluorescence intensity indicates FoxP3 expression levels in the T cells of wild type and PR (−/−) mice. The data were obtained from 4 independent experiments. *Significant differences between control and P4 groups. **Significant differences between wild type and PR (−/−) mice.