TABLE 4.
Characterized Pap acyltransferases from Mycobacterium or Amycolatopsis and sequence region containing the proposed active-site motif HxxxDx14Y
| Protein | Species | HxxxDx14Y motif region | Reference |
|---|---|---|---|
| PapA1 | Mycobacterium tuberculosis | SIDHLHADGQFVGVGLMEFQSMYTAL | 165 |
| PapA2 | M. tuberculosis | SIAHLCVDPMIVGVLFIEIHMMYSAL | |
| PapA3 | M. tuberculosis | SVDHVHVDAMIVGVTLMEFHLMYAAL | 164 |
| PapA4 | M. marinum | SVDHLNVDAMFISAVFWEIEAMYNTL | 167 |
| PapA5 | M. tuberculosis | YLHHCMADGHHGAVLVDELFSRYTDA | 62 |
| PapA5 | M. marinum | YVHHSLADAHHLGSLLDELLSRYTDV | 163 |
| Rif-Orf20 | Amycolatopsis mediterranei | AIQHSVADAHHATAILSALWSCYTDV | 168 |
a
Strictly conserved residues are in bold; residues resembling the AtfA active-site motif (HHxxxDG) are underlined.