Fig 1.

Translation elongation (not to scale). Eukaryotic elongation factor 1A (eEF1A; blue circle) in complex with GTP (red star) delivers an aminoacylated tRNA to the A site of the ribosome (yellow). GTP is hydrolyzed when codon-anticodon recognition occurs, and eEF1A-GDP is released from the ribosome. The GTP exchange factor for eEF1A is a complex with three subunits: eEF1B is shown in orange, eEF1G in green, and eEF1D in purple. This complex promotes the exchange of the bound GDP for GTP to regenerate active eEF1A-GTP.