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Demonstration of the breadth of coverage afforded by the bivalent fHBP vaccine: cumulative coverage of fHBP variants. Variants shown to be killed by anti-fHBP bivalent immune sera from adults (23) are indicated on the x axis. The prevalence of these variants in a systematically collected set of 1,263 invasive MnB disease isolates from the United States and Europe (29) is shown on the left y axis, with the cumulative prevalence indicated by the red line (right y axis).
