Model for evolution of characterized C. perfringens toxin plasmids. See the text for discussion of the possible evolution of pIP401 (230), pCW3 (236), pJIR3535 (netB+) (19), pCP8533etx (etx+
cpb2+) (14), pCPF5603 (cpe+
cpb2+) (13), pCPPB-1 (cpe+
iota+) (23), and pCPF4969 (cpe+) (13). Each box color depicts a different region of importance on the toxin plasmids, as indicated.