Table 3.
In vitro Growth Inhibitory Effects of RABI compounds without B ring substitution
| Structure | ID | R1 | R2 | IC50 ± SEM (nM)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LNCaP | PC3 | PPC1 | DU145 | A375 | WM164 | MDA-MB-435 | MDA-MB-435/LCC6MD R1 | ||||
|
11a | H | H | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 |
| 11b | F | F | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | |
| 11c | Cl | Cl | > 50000 | > 50000 | > 50000 | > 50000 | 35674 ± 665 | > 50000 | > 50000 | > 50000 | |
| 11d | Br | Br | 16930 ± 6183 | 18940 ± 1068 | 13210 ± 706 | 25490 ± 5144 | 24960 ± 35 | 26320 ± 211 | 14355 ± 178 | 17814 ± 155 | |
| 11e | CF3 | CF3 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | 26460 ± 533 | |
| 11f | Me | Me | 3762 ± 1720 | 5159 ± 386 | 2405 ± 308 | 6541 ± 460 | 2535 ± 30 | 3693 ± 18 | 3020 ± 23 | 3271 ± 33 | |
| 11g | OMe | OMe | 6419 ± 4365 | 23370 ± 1471 | 38150 ± 2325 | 9839 ± 503 | > 50000 | > 50000 | > 50000 | > 50000 | |
| 11h | N(CH3)2 | N(CH3)2 | ND | ND | ND | ND | > 50000 | > 50000 | > 50000 | > 50000 | |
| 11i | OH | OH | ND | ND | ND | ND | 38769 ± 97 | 48218 ± 113 | 47986 ± 104 | 21421 ± 93 | |
| 12a | H | 3,4,5-(OMe)3 | 6 ± 1 | 14 ± 1 | 13 ± 0.3 | 22 ± 2 | 9 ± 6 | 14 ± 3 | 24 ± 3 | 11 ± 2 | |
| 12b | F | 3,4,5-(OMe)3 | 114 ± 7 | 196 ± 6 | 134 ± 0.1 | 353 ± 10 | 197 ± 15 | 298 ± 13 | 320 ± 14 | 263 ± 10 | |
| 12c | Cl | 3,4,5-(OMe)3 | 22 ± 6 | 64 ± 7 | 51 ± 1 | 125 ± 12 | 51 ± 13 | 63 ± 11 | 106 ± 15 | 75 ± 11 | |
| 12d | Br | 3,4,5-(OMe)3 | 15 ± 5 | 33 ± 2 | 30 ± 1 | 66 ± 2 | 29 ± 7 | 31 ± 4 | 58 ± 14 | 43 ± 11 | |
| 12e | CF3 | 3,4,5-(OMe)3 | 47 ± 35 | 93 ± 3 | 74 ± 2 | 210 ± 18 | 123 ± 18 | 143 ± 8 | 120 ± 15 | 175 ± 9 | |
| 12f | CH3 | 3,4,5-(OMe)3 | 13 ± 1 | 19 ± 1 | 18 ± 0.3 | 30 ± 4 | 13 ± 2 | 14 ± 3 | 27 ± 11 | 21 ± 5 | |
| 12g | OMe | 3,4,5-(OMe)3 | 30 ± 14 | 61 ± 4 | 54 ± 1 | 210 ± 147 | 33 ± 8 | 41 ± 12 | 55 ± 9 | 59 ± 18 | |
| 12h | N(CH3)2 | 3,4,5-(OMe)3 | 96 ± 6 | 118 ± 17 | 120 ± 12 | 263 ± 16 | 141 ± 23 | 129 ± 19 | 200 ± 20 | 162 ± 12 | |
| 12i | OH | 3,4,5-(OMe)3 | 219 ± 101 | 155 ± 23 | 122 ± 6 | 518 ± 10 | 487 ± 35 | 549 ± 24 | 669 ± 31 | 455 ± 29 | |
| 13a | 3,4,5-(OMe)3 | H | 195 ± 91 | 632 ± 42 | 408 ± 11 | 1301 ± 264 | 1023 ± 23 | 1273 ± 30 | 4606 ± 78 | 5770 ± 63 | |
| 13d | 3,4,5-(OMe)3 | Br | 131 ± 175 | 371 ± 247 | 106 ± 3 | 429 ± 0.2 | 136 ± 12 | 177 ± 16 | 186 ± 11 | 161 ± 11 | |
| 13g | 3,4,5-(OMe)3 | OMe | 708 ± 334 | 10390 ± 6646 | 5685 ± 325 | >50000 | 35414 ± 106 | 36007 ± 98 | 10956 ± 96 | 11428 ± 87 | |
| 13h | 3,4,5-(OMe)3 | N(CH3)2 | ND | ND | ND | ND | 47878 ± 563 | 46131 ± 98 | 29175 ± 88 | 40618 ± 112 | |
| 13i | 3,4,5-(OMe)3 | OH | ND | ND | ND | ND | > 50000 | > 50000 | > 50000 | > 50000 | |
| 14 | 3,4,5-(OMe)3 | 3,4,5-(OMe)3 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | > 50000 | |
ND: Not Determined