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In vitro Growth Inhibitory Effects of RABI Compounds Comparison to Other Anticancer Drugs on Multidrug-Resistant Melanoma Cells and Parent Cell Line
| ID | IC50 ± SEM (nM)
|
||
|---|---|---|---|
| MDA-MB-435 | MDA-MB-435/LCC6MDR1 | Resistance Index | |
| 12a | 24 ± 3 | 11 ± 2 | 0.5 |
| 12d | 58 ± 14 | 43 ± 11 | 0.7 |
| 12e | 27 ± 11 | 21 ± 5 | 0.8 |
| colchicine | 11 ± 2 | 643 ± 9 | 58.5 |
| vinblastine | 0.4 ± 0.1 | 11 ± 1 | 27.5 |
| paclitaxel | 4 ± 1 | 277 ± 41 | 69.3 |
