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. Author manuscript; available in PMC: 2014 Mar 29.
Published in final edited form as: Circ Res. 2013 Mar 29;112(7):1073–1084. doi: 10.1161/CIRCRESAHA.113.300937

Table 1.

Specific miRNAs, their targets and effects in cardiovascular calcification

miRNA/Regulation Target Cell source Observation by using inhibitor/mimic Reference number
miR-125b
↓		 SP7 Human CASMC Inhibit ALP activity and matrix mineralization 23
miR-141
↓		 - Porcine VIC Blocks TGF-β-mediated ALP activity 44
miR-223
↑		 Mef2c
RhoB
SMα actin 		Human SMC Enhance VSMC migration 32
miR-143
miR-145
↓		 KLF4 Human SMC - 32
miR-30d/e
↓		 Runx2 Human SMC Inhibit ALP activity and matrix mineralization 42
miR-204
↓		 Runx2 Mouse SMC Inhibit ALP activity and osteocalcin secretion 28
miR-29a/b
↓		 ADAMTS-7 Rat SMC Inhibit matrix mineralization 52
miR-135a*, miR-762, miR-714, or miR-712*
↑		 NCX
PMCA
NCKX4 		Mouse SMC Promote matrix mineralization 25

Bold; direct binding to 3′UTR not shown in this study, Arrow indicate regulation of miRNA

ALP, alkaline phosphatase; CASMC, coronary artery SMC