FIGURE 1.

KCa3.1 regulates PDGF-induced rise in [Ca²⁺]_i and signaling pathway activation. A and B, lowering [Ca²⁺]_i with BAPTA suppressed (A) and a forced rise in [Ca²⁺]_i with A23187 enhanced (B) PDGF-induced proliferation of HCSMCs. C and D, both blockade with TRAM-34 and siRNA knockdown of KCa3.1 reduced PDGF-induced rise in [Ca²⁺]_i (C) and inhibited PDGF-induced expression of c-Fos and NOR-1 (D). *, p < 0.05 versus control, and †, p < 0.05 versus PDGF alone. neg. siRNA, negative control siRNA.