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. 2013 Apr 15;288(22):15947–15958. doi: 10.1074/jbc.M112.426791

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 7. — Beclin 1 overexpression rescues caspase 1^−/− mice from excessive liver injury. A, effectiveness of adenoviral gene expression in liver after tail vein injection with adenovirus encoding GFP as control (ad-Ctrl) (left panel, scale bar = 50 μm) or mouse beclin 1 (ad-beclin1) (right panel). B, plasma alanine aminotransferase (ALT) (n = 6). Data are mean ± S.E. *, p < 0.05. C, liver HNE adducts. Data are mean ± S.E., n = 5. *, p < 0.05. D, liver cytoplasmic cytochrome c (n = 5). Data are mean ± S.D. #, p < 0.05, WT versus caspase 1^−/−. *, p < 0.05, ad-Ctrl versus ad-beclin 1 in mice given ad-GFP or ad-beclin1 (ad-b1) 48 h prior to hemorrhagic shock and 4.5 h of resuscitation (HS+4.5R).