FIGURE 9.

Effect of BZ194 on arrhythmia induction in vivo. a, mice (n = 6) were challenged by two consecutive injections (30 min apart) of NaCl or Iso (2 mg/kg) 4 h after injection of either NaCl, DMSO (1 mg/kg), or DMSO + BZ194 (BZ) (180 mg/kg). b, representative ECG tracing following an injection of BZ194 (180 mg/kg) alone. Representative recordings of arrhythmias were evoked by the injection of Iso including a premature ventricular beat (PVB, c), salve of PVBs (d), bigeminy (e), and VT (f). Effect of NaCl, Iso, DMSO, and BZ194 on the occurrence of (g) PVBs and bigeminy, and (h) salves of PVBs and VTs. Lines depict responses in individual mice. i, summary analysis of the total number of arrhythmic events. Significant differences are indicated by ***, p < 0.001, ANOVA followed by a paired Bonferroni's post hoc test; n.s., not significant.