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Endocytosed Runx2 retains its functionality after being expressed as a fusion protein with DSS. The graph shows the changes in expression pattern of three Runx2 downstream target genes upon treatment of HMSC with Runx2-DSS fusion protein for 24 and 48 h. No change was observed after 24 h post treatment. However, the expression levels of the three genes tested increased after 48 h of treatment. ALP, alkaline phosphatase.
