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CRTC2 ASO slows glucagon clearance. A, elevated fasting plasma glucagon in normal, nondiabetic rats. B, accumulation of infused plasma glucagon in CRTC2 ASO-treated normal rats. C, glucagon clearance (n = 4–8/group). *, p < 0.05; **, p < 0.01 Control ASO versus CRTC2 ASO; Student's t test, Two-way ANOVA. Error bars, S.E.
