Table 4.
Agreement in responsea and remissionb ratings for patient-rated QIDS-SR16 compared with clinician-rated HAM-D17 from baseline through acute-phase week 10; n (%) of patients.
| HAM-D17 |
|||||||
|---|---|---|---|---|---|---|---|
| Responder |
Remitter |
||||||
| QIDS-SR16 | Yes | No | κ | Yes | No | κ | |
| Baselinec | Yes | - | - | - | 3 (100) | −0.002 | |
| No | - | 1032 (100) | 1 (<1) | 1028 (99) | |||
| Week 1 | Yes | 26 (22) | 92 (78) | 0.23* | 7 (25) | 21 (75) | 0.21* |
| No | 34 (4) | 837 (96) | 24 (2) | 937 (98) | |||
| Week 2 | Yes | 110 (52) | 103 (48) | 0.45* | 24 (39) | 38 (61) | 0.34* |
| No | 69 (10) | 657 (90) | 39 (4) | 838 (96) | |||
| Week 3 | Yes | 190 (65) | 103 (35) | 0.44* | 47 (47) | 53 (53) | 0.35* |
| No | 122 (20) | 499 (80) | 73 (9) | 741 (91) | |||
| Week 4 | Yes | 283 (74) | 102 (26) | 0.46* | 105 (66) | 53 (34) | 0.46* |
| No | 145 (27) | 395 (73) | 110 (14) | 657 (86) | |||
| Week 6 | Yes | 396 (83) | 80 (17) | 0.48* | 155 (80) | 40 (20) | 0.45* |
| No | 147 (36) | 262 (64) | 168 (24) | 522 (76) | |||
| Week 8 | Yes | 441 (91) | 43 (9) | 0.50* | 210 (83) | 43 (17) | 0.48* |
| No | 141 (44) | 178 (56) | 160 (29) | 390 (71) | |||
| Week 10 | Yes | 498 (95) | 26 (5) | 0.33* | 270 (90) | 29 (10) | 0.45* |
| No | 174 (67) | 87 (33) | 195 (40) | 291 (60) | |||
HAM-D17, 17-item Hamilton Rating Scale for Depression; κ, kappa statistic; QIDS-SR16, 16-item Quick Inventory of Depressive Symptomatology—Self-Report.
a
Response: ≥50% reduction from baseline on HAM-D17 total score and QIDS-SR16 total score.
b
Remission: HAM-D17 total score≤7, QIDS-SR16 total score≤5.
c
QIDS-SR16 values missing for ≥1.0% of patients: baseline, 15/1047 (1.4%).
*
P<0.0001.