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Effect sizes used in the simulation study for each causal variant k
| Deleterious effects only | 1.2 | 2 | 3 | 0.4|log10MAFk| |
| Deleterious and protective effects | –1.2, 1.2 | –2, 2 | –3, 3 | −0.4|log10MAFk|, 0.4|log10MAFk| |
| In the presence of different directions of effect (second line of the table), the two effect sizes reported are evenly distributed among the causal variants. | ||||
