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. 2013 May 24;123(6):2421–2433. doi: 10.1172/JCI65952

Figure 6. Insulin signaling in osteoblasts promotes male fertility in an osteocalcin-dependent manner.

Figure 6

(A) Sperm counts, (BD) testis, epididymal, and seminal vesicle weights normalized to BW (mg/g of BW); (E) circulating testosterone levels in InsRosb+/– (n = 5), InsRosb+/–;Osteocalcin+/– (n = 6), and InsRosb+/–; Gprc6a+/– (n = 6) versus control (n > 8) male mice. All analyses presented were performed on nonbreeder mix background (129/Sv: 75%; C57BL/6J: 25%) mice. *P < 0.05; **P < 0.01.