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. 2013 May 24;123(6):2447–2463. doi: 10.1172/JCI64859

Figure 10. i.t. low-dose immunomodulation cures established CNS lymphoma.

Figure 10

The CNS lymphoma burden assessed over time by bioluminescence for 1 representative mouse of each treatment group and the survival of the whole group (5 mice per group). MTX, 400 mg/kg s.c. MTX, followed by 12 mg/kg s.c. calcium leucovorin rescue started 16 hours later and given once every 2 hours for a total of 5 doses; CTX, 100 mg/kg i.p CTX for 2 subsequent days; αId, 100 mg i.p.; i.t. CpG and 1/10 or 1/100 doses of αOX40/CTLA4.