Figure 7. Disruption of HSPG-mediated TRL clearance enhances atherosclerosis development.

(A and B) Lipoproteins from pooled plasma samples (n = 6) from Apoe^–/–Ndst1^f/fAlbCre^– (filled circles) and Apoe^–/–Ndst1^f/fAlbCre⁺ (open circles) mice were analyzed by FPLC gel filtration, and the amount of (A) triglyceride and (B) cholesterol was determined. (C and D) 6-month-old Apoe^–/–Ndst1^f/fAlbCre^– (n = 8) and Apoe^–/–Ndst1^f/fAlbCre⁺ (n = 12) mice on standard chow diets were analyzed for spontaneous atherosclerosis development. (C) Plaque formation in the aortic arch from males (squares) and females (circles) was quantified. (D) 3 representative images of stained aortas from females for each genotype.