Figure 1. Unsupervised hierarchical clustering of miRNA expression profiles.

Unsupervised hierarchical clustering was performed using log₂ relative frequencies (RF) of miRNA precursor cluster sequence reads for the given cell line and FFPE tissue samples; MCV status is also indicated where available. miRNA precursor clusters were selected from the top 85% expressed miRNA precursor clusters across all samples. The number of members per precursor cluster is indicated in parentheses following the miRNA gene name; precursor clusters are named according to Farazi et al. (30). miR-205 and miR-375 expression values for all samples are indicated by red and green arrows, respectively.