Figure 3. Lamin B1 overexpression results in seizures.

Spontaneous EEG activity over the parietal cortex of Lmnb1^BAC and WT mice was recorded for 24 hours. (A) EEG recordings from the left and right hemisphere, respectively, are shown for a representative transgenic mouse overexpressing lamin B1 (top traces) or a WT control (bottom traces). Arrowheads mark interictal spikes. (B) Quantification of interictal spikes over 24-hour recordings indicates the occurrence of spontaneous epileptiform activity in Lmnb1^BAC mice specifically. n = 10 animals per genotypic group. (C) Histogram quantifying percentage of animals seizing after the administration of 30 mg/kg of PTZ. n = 9 animals per genotypic group. Values are expressed as means ± SEM. *P < 0.05.