Figure 6. PLP-LMNB1^Tg mice exhibit demyelination, aberrant myelin formation, and axonal degeneration.

(A and B) PLP-LMNB1^Tg animals exhibited demyelination compared with WT controls, quantified by g ratio of 150–200 axons, P < 0.05. (C and D) PLP-LMNB1^Tg animals showed aberrant myelin formation and axonal degeneration. (E and F) Demyelinating axons (e.g., arrow) and axons with normal myelin thickness (e.g., arrowhead) were frequently observed in PLP-LMNB1^Tg mice (E) but not in WT controls (F). Myelin-axon structure also appeared irregular and nonuniform in PLP-LMNB1^Tg mice compared with WT controls. n = 4 animals per genotype. Scale bars: 2 μm.