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Rate constants and correlation coefficients of the dissolution–diffusion kinetic models applied to VP16 release from VP16-LDH
| Kinetic model | Kinetic equation | R2 (pH = 7.4) | R2 (pH = 4.6) |
|---|---|---|---|
| Zero-order | Mt – M0 = kt + a | 0.4225 | 0.6624 |
| First-order | Ln (Mt/M0) = −kt + a | 0.5931 | 0.8345 |
| Parabolic diffusion model | (1 – Mt/M0)/t) = kt−0.5 + a | 0.9697 | 0.9783 |
| Modified Freundlich model | 1 – Mt/M0 = kta | 0.9230 | 0.8977 |
Abbreviations: VP16, etoposide; LDH, layered double hydroxide.
