Table 2.
Mean (SE) for Alcohol Craving, Anxiety, and Cortisol to Corticotropin Ratio (Adrenal Sensitivity Measure) Predictor Variables From the Experimental Manipulation for the 93 Alcohol-Dependent Individuals in Study 2a
| Mean (SE) |
|||
|---|---|---|---|
| Predictor Variable | Baseline | Peak | Area Under the Curve |
| Stress exposure | |||
| Alcohol craving | 0.35 (0.11) | 2.63 (0.31) | 1.01 (0.17) |
| Anxiety | 0.76 (0.17) | 4.47 (0.28) | 1.56 (0.17) |
| Corticotropin level, pg/mL | 22.16 (1.24) | 26.29 (1.33) | 21.73 (1.14) |
| Plasma cortisol level, μg/dL | 9.87 (0.36) | 11.22 (0.40) | 8.53 (0.34) |
| Cortisol to corticotropin ratio | 0.58 (0.05) | 0.53 (0.04) | 0.52 (0.05) |
| Alcohol cue exposure | |||
| Alcohol craving | 0.45 (0.16) | 3.35 (0.32) | 1.12 (0.17) |
| Anxiety | 0.76 (0.16) | 3.51 (0.29) | 1.25 (0.16) |
| Corticotropin level, pg/mL | 22.32 (1.26) | 26.69 (1.34) | 22.15 (1.15) |
| Plasma cortisol level, μg/dL | 9.92 (0.39) | 11.30 (0.45) | 8.85 (0.37) |
| Cortisol to corticotropin ratio | 0.59 (0.05) | 0.53 (0.04) | 0.52 (0.05) |
| Neutral, relaxing exposure | |||
| Alcohol craving | 0.38 (0.12) | 0.80 (0.18) | 0.45 (0.13) |
| Anxiety | 0.81 (0.16) | 1.96 (0.22) | 0.82 (0.15) |
| Corticotropin level, pg/mL | 23.15 (1.28) | 26.80 (1.35) | 21.99 (1.17) |
| Plasma cortisol level, μg/dL | 10.26 (0.43) | 11.07 (0.45) | 8.37 (0.34) |
| Cortisol to corticotropin ratio | 0.60 (0.05) | 0.53 (0.04) | 0.49 (0.04) |
SI conversion factors: To convert corticotropin to picomoles per liter, multiply by 0.22; cortisol to nanomoles per liter, multiply by 27.588.
a
Alcohol craving and anxiety scores are from 10-point visual analog scales.