Scheme 1.
General synthetic route to 3-benzylidene-4-chromanones 5a–k.Reagents and conditions: (a) 3-chloropropionic acid, CF3SO3H; (b) 2.0 M NaOH; (c) methyl iodide, K2CO3, DMF; (d) appropriate aldehyde, HCl (gas), ROH.
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