Table 4.
Top networks and biological functions of miRNAs dysregulated in sALS
|
Top network functions for predicted targets of miRNAs up-regulated in sALS | ||
|
Associated network functions |
Score |
|
| Cellular development, nervous system development and function, tissue development |
3 |
|
| Cellular assembly and organization, lipid metabolism, nucleic acid metabolism |
2 |
|
|
Top biological functions for predicted targets of miRNAs up-regulated in sALS | ||
| |
P-value |
No. of molecules |
|
Diseases and disorders |
|
|
| Reproductive system disease |
2.13E-03-2.13E-03 |
2 |
| Inflammatory response |
2.92E-03-2.92E-03 |
1 |
| Cancer |
6.81E-03-4.35E-02 |
3 |
| Hematological disease |
6.81E-03-6.81E-03 |
1 |
| Immunological disease |
6.81E-03-6.81E-03 |
1 |
|
Molecular and cellular functions |
|
|
| Antigen presentation |
2.92E-03-2.92E-03 |
1 |
| Cell to cell signaling and interaction |
2.92E-03-2.92E-03 |
1 |
|
Physiological system development and function |
|
|
| Hematological system development and function |
2.92E-03-2.92E-03 |
1 |
| Immune cell trafficking |
2.92E-03-2.92E-03 |
1 |
|
Top network functions for predicted targets of miRNAs down-regulated in sALS | ||
|
Associated network functions |
Score |
|
| Cancer, gastrointestinal disease, hepatic system disease |
26 |
|
| Cancer, reproductive system disease, connective tissue disorders |
24 |
|
| Cell death, cancer, cell cycle |
18 |
|
| Cancer, reproductive system disease, gastrointestinal disease |
18 |
|
| Reproductive system disease, cancer, cellular growth and proliferation |
11 |
|
|
Top biological functions for predicted targets of miRNAs down-regulated in sALS | ||
| |
P-value |
No. of molecules |
|
Diseases and disorders |
|
|
| Reproductive system disease |
4.31E-88-2.58E-03 |
93 |
| Inflammatory disease |
3.04E-47-4.99E-02 |
55 |
| Renal and urological disease |
3.04E-47-3.95E-03 |
52 |
| Cancer |
6.09E-41-4.40E-02 |
81 |
| Gastrointestinal disease |
1.44E-21-1.25E-02 |
48 |
|
Molecular and cellular functions |
|
|
| Cellular development |
1.51E-07-4.40E-02 |
22 |
| Cellular growth and proliferation |
1.51E-07-4.99E-02 |
31 |
| Cell cycle |
2.16E-05-4.40E-02 |
11 |
| Cellular movement |
5.09E-04-4.99E-02 |
15 |
| Cell death |
7.84E-04-4.10E-02 |
12 |
|
Physiological system development and function |
|
|
| Organismal development |
2.33E-11-6.61E09 |
7 |
| Connective tissue development and function |
2.16E-05-2.16E-05 |
4 |
| Hair and skin development and function |
8.96E-03-8.96E-03 |
1 |
| Nervous system development and function |
8.96E-03-8.96E-03 |
1 |
| Respiratory system development and function | 8.96E-03-3.54E-02 | 3 |