Table 1.
Characteristics of studies included in the meta-analysis
| References | First author’s name | Year of publication | Country of origin | Cancer type | Ethnicity | SNPs | Source of control groups | Matching criteria | Genotyping methods | Case | control | MAF | HWE |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 18 |
Rong-rong Liu |
2008 |
Hunan, China |
ALL |
Asian |
C3435T,C1236T,G2677T,G2677A |
HB |
Age, gender, weight |
PCR-RFLP |
48 |
100 |
0.17;0.24;0.04 |
0.60;0.21;0.07 |
| 19 |
Zhi-zhuo Du |
2010 |
Suzhou, China |
ALL |
Asian |
C3435T,C1236T,G2677T/A |
HB |
Age, gender |
SNP-shot |
176 |
170 |
0.30;0.38;0.27 |
0.00;0.28;0.23 |
| 2 |
Kevin Y. Urayama |
2007 |
Northern and Central California, USA |
ALL |
|
C3435T,C1236T,G2677T/A |
HB |
Age, gender, Hispanic status |
PCR-SBEP |
294 |
369 |
0.25;0.21;0.18 |
0.30;0.13;0.18 |
| 3 |
Hiroyoshi Hattori |
2007 |
Japan |
ALL |
Asian |
C3435T |
HB |
Age, gender |
Taqman |
622 |
96 |
0.18 |
0.3 |
| 20 |
Jamroziak K |
2004 |
Poland |
ALL |
Caucasian |
C3435T |
PB |
Age, gender, |
PCR-RELP |
113 |
175 |
0.24 |
0 |
| 21 |
Evelia Leal-Ugarte |
2008 |
Mexico |
ALL |
|
C3435T |
PB |
Gender |
PCR-RELP |
107 |
111 |
0.28 |
0.02 |
| 22 |
A’ gnes F. Semsei |
2008 |
Hungary |
ALL |
Caucasian |
C3435T,G2677T/A |
PB |
Age, gender, risk group |
PCR-RELP |
378 |
189 |
0.29;0.28 |
0.07;0.13 |
| 23 |
Vibeke Andersen |
2009 |
Danish |
colorectal cancer |
Caucasian |
C3435T,G-rs3789244-A |
PB |
Age, Gender, |
TaqMan |
359 |
765 |
0.33 |
0.47 |
| 24 |
Daniele Campa |
2012 |
Czech Republic |
colorectal cancer |
Caucasian |
C3435T |
HB |
Age, Gender, |
Taqman |
699 |
622 |
0.29 |
0.79 |
| 24 |
Daniele Campa |
2012 |
Southwest Germany |
colorectal cancer |
Caucasian |
C3435T |
HB |
Age, Gender, county of residence |
Taqman |
1809 |
1853 |
0.28 |
0.91 |
| 24 |
Daniele Campa |
2012 |
Southwest Germany |
colorectal cancer |
Caucasian |
C3435T |
PB |
Age, Gender, |
Taqman |
2169 |
1634 |
0.29 |
0.62 |
| 25 |
Urosˇ Potocnik |
2008 |
Slovenia |
MSI-H colorectal cancer |
Caucasian |
C3435T,C1236T,G2677T |
HB |
Age, Gender, |
TaqMan |
38 |
355 |
0.30;0.18;0.19 |
0.66;0.33;0.24 |
| 26 |
Nizar M Mhaidat |
2011 |
Jordan |
HL |
Asian |
C3435T |
HB |
Age |
PCR-RFLP |
130 |
120 |
0.35 |
0.11 |
| 27 |
Sun-Young Bae |
2006 |
Korea |
colorectal cancer |
Asian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
111 |
93 |
0.16 |
0.01 |
| 28 |
Azam Khedri |
2011 |
Iran |
colorectal cancer |
Caucasian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
118 |
137 |
0.35 |
0.56 |
| 29 |
Mateusz Kurzawski |
2005 |
Poland |
colorectal cancer |
Caucasian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
184 |
188 |
0.29 |
0.27 |
| 30 |
Chiko Komoto |
2006 |
Japan |
colorectal cancer |
Asian |
C3435T,C1236T,G2677T |
HB |
Age, Gender, |
TaqMan |
48 |
154 |
0.16;0.375;0.36 |
0.62;0.36;0.37 |
| 30 |
Chiko Komoto |
2006 |
Japan |
esophageal squamous cell carcinoma |
Asian |
C3435T,C1236T,G2677T |
HB |
Age, Gender, |
TaqMan |
47 |
154 |
0.17;0.39;0.34 |
0.66;0.34;0.64 |
| 31 |
Bo-In Lee |
2006 |
Korea |
colorectal cancer |
Asian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
64 |
64 |
0.13 |
0.15 |
| 32 |
Elena Osswald |
2006 |
Russia |
colorectal cancer |
Caucasian |
C3435T,G2677T/A |
HB |
Age, Gender, Smoking intensity |
PCR-RFLP |
285 |
275 |
0.26;0.20 |
0.35;0.42 |
| 33 |
Mariusz Panczyk |
2009 |
Poland |
colorectal cancer |
Caucasian |
C3435T,C1236T,G2677T |
HB |
Age, Gender, |
PCR-RFLP |
95 |
95 |
0.20;0.17;0.18 |
0.99;0.72;0.60 |
| 34 |
Darinka Todorova Petrova |
2008 |
Bulgaria |
colorectal cancer |
Caucasian |
C3435T,G2677T |
HB |
Age, Gender, |
RT-PCR |
146 |
160 |
0.25;0.21 |
0.73;0.32 |
| 35 |
J Sainz |
2011 |
South Germany |
colorectal cancer |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR |
1765 |
1784 |
0.27 |
0.6 |
| 36 |
Cizmarikova |
2010 |
Eastern Slovakia |
breast cancer |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
221 |
113 |
0.27 |
0.6 |
| 37 |
M. Taheri |
2010 |
Iran |
breast cancer |
Caucasian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
54 |
50 |
0.26 |
0.61 |
| 38 |
Tatari F |
2009 |
North east of Iran |
breast cancer |
Caucasian |
C3435T |
HB |
Gender, |
PCR |
106 |
77 |
0.29 |
0.59 |
| 39 |
Joseph George |
2009 |
India |
breast cancer |
Asian |
C3435T |
HB |
Gender, |
PCR |
86 |
68 |
0.15 |
0.7 |
| 40 |
Henriquez-Hernandez |
2009 |
Spain |
breast cancer |
Caucasian |
C3435T |
HB |
Gender, |
PCR-RFLP |
135 |
301 |
0.19 |
0.66 |
| 41 |
Nordgard |
2007 |
Norway |
breast cancer |
Caucasian |
C3435T,C1236T,G2677T/A |
N.A. |
Age, Gender, |
PCR-RFLP |
109 |
93 |
0.13;0.26;0.26 |
0.27;0.16;0.03 |
| 42 |
Sebahat Turgut |
2007 |
Turkey |
breast cancer |
Caucasian |
C3435T |
PB |
Gender, |
PCR-RFLP |
57 |
50 |
0.24 |
0.62 |
| 43 |
Wu H |
2012 |
China |
breast cancer |
Asian |
C3435T,C1236T,G2677T/A |
PB |
Age, Gender, |
PCR-RFLP |
1173 |
1244 |
0.17;0.41;0.17 |
0.01;0.04;0.94 |
| 44 |
Z Sabahi |
2010 |
Iran |
Gastric cancer |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR |
48 |
131 |
0.3 |
0.58 |
| 45 |
Mitsushige Sugimoto |
2008 |
Japan |
Gastric cancer |
Asian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
150 |
168 |
0.17 |
0.68 |
| 46 |
Tomomitsu Tahara |
2006 |
Japan |
Gastric cancer |
Asian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
157 |
104 |
0.21 |
0.64 |
| 47 |
P.M. MROZIKIEWICZ |
2007 |
Poland |
endometrial cancer |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR |
198 |
488 |
0.26 |
0.61 |
| 48 |
Federica Gemignani |
2007 |
six Central and Eastern European countries |
lung cancer |
Caucasian |
C3435T,G2677T/A |
HB |
Age, Gender, |
TaqMan |
299 |
317 |
0.24;0.21 |
0.62;0.01 |
| 49 |
S Haenisch |
2007 |
Germany |
renal cell cancer |
Caucasian |
C3435T,G2677T/A |
PB |
Age, Gender, |
PCR-RFLP |
82 |
164 |
0.31;0.22 |
0.58;0.14 |
| 50 |
Krzysztof Jamroziak |
2006 |
Poland |
AML |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
180 |
180 |
0.23 |
0.64 |
| 51 |
Katie L. Miller |
2005 |
USA |
Glioma |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
382 |
464 |
0.25 |
0.61 |
| 52 |
Krzysztof Jamroziak |
2006 |
Poland |
B-cell CLL |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
110 |
201 |
0.2 |
0.65 |
| 53 |
Michael Siegsmund |
2002 |
Germany |
clear cell renal cell carcinoma (CCRCC) |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
179 |
150 |
0.29 |
0.59 |
| 53 |
Michael Siegsmund |
2002 |
Germany |
non-CCRCC |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
83 |
150 |
0.3 |
0.58 |
| 54 |
Guillermo Gervasini |
2006 |
Spain |
lung cancer |
Caucasian |
C3435T,G2677T/A |
PB |
Age, Gender, |
TaqMan |
96 |
86 |
0.26;0.31 |
0.61;0,。60 |
| 55 |
Soya Sisy Sam |
2007 |
India |
upper aerodigestive tract (UADT) cancers |
Asian |
C3435T |
HB |
Age, Gender, |
PCR-RFLP |
219 |
210 |
0.35 |
0.55 |
| 56 |
Krzysztof Jamroziak |
2008 |
Poland |
multiple myeloma |
Caucasian |
C3435T,C1236T,G2677T/A |
PB |
Age, Gender, |
PCR-RFLP |
111 |
96 |
0.19;0.15;0.18 |
0.66;0.01;0.55 |
| 57 |
V Rocha |
2008 |
France |
leukemia |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
107 |
107 |
0.2 |
0.65 |
| 58 |
STEPHEN DRAIN |
2009 |
UK |
plasma cell myeloma |
Caucasian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
92 |
92 |
0.28 |
0.6 |
| 59 |
G. Penna |
2010 |
Italy |
B-cell CLL |
Caucasian |
C3435T,G2677T |
PB |
Age, Gender, |
PCR-RFLP |
125 |
125 |
0.25;0.30 |
0.62;0.00 |
| 60 |
The MARIE-GENICA Consortium |
2010 |
Germany |
breast cancer |
Caucasian |
C3435T |
PB |
Age, Gender, |
MALDI-TOFMS |
3148 |
5486 |
0.22 |
0.64 |
| 61 |
HYUN CHANG |
2009 |
Korea |
Gastric cancer |
Asian |
C3435T,G2677T/A |
PB |
Age, Gender, |
PCR |
43 |
118 |
0.34;0.23 |
0.56;0.21 |
| 62 |
D Nageswara Rao |
2010 |
India |
AML |
Asian |
C3435T |
PB |
Age, Gender, |
PCR-RFLP |
143 |
249 |
0.28 |
0.6 |
| 62 | D Nageswara Rao | 2010 | India | ALL | Asian | C3435T | PB | Age, Gender, | PCR-RFLP | 147 | 249 | 0.37 | 0.54 |
Abbreviations: HB: hospital-based; PB: population-based; PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism; MAF: minor allele frequency; APEX: arrayed primer extensions.