Table 4.

Studies presenting data on costs associated with adherence or compliance

Study	Disease	Type of evaluation	Results	Study conclusion
Brown46	Angina	Decision-analytic model	• Estimated total NHS annual cost for ISMN OD management: GB £248 • Estimated total NHS annual cost for ISMN OD management: GB £250	• Fewer health service resources were consumed by patients treated on OD regimen, with a higher compliance rate, compared to a BID regimen
Sidhu9	Renal transplant	Budget impact analysis	• Once daily tacrolimus yielded cumulative cost savings of GB £104,534	• Use of OD therapy could yield cost savings over five years in comparison to BID therapy of tacrolimus
Abecassis61	Renal transplant	Cost-effectiveness analysis	• Total direct cost with OD therapy: US$228,734 • Total direct cost with BID therapy: US$238,144	• Tacrolimus OD resulted in a reduction of costs relative to BID tacrolimus • Tacrolimus OD was the dominant therapy in the cost-effectiveness analysis

Note: 1 GBP = 1.5 USD.

Abbreviations: BID, twice daily; ISMN, isosorbide mononitrate nitroglycerin; OD, once daily dosing; NHS, UK National Health Service.