Table 2. Unit costs for resource utilization in euros (€) and other parameters used in the economic model.
| Base case | Distribution | References | |
| Cost parameters (€) | |||
| Overhead costs of the immunization program | |||
| Routine immunization of toddlers | 62,476 | Fixed | [20] |
| Booster-dose at the age of 12 years | 62,476 | Fixed | [20] |
| Vaccine dose | |||
| MenACWY | 42.72 | Fixed | [23] |
| MenC | 55.11 | Fixed | [24] |
| Other costs | |||
| Administration costs routine infant vaccination | 6.30 | Fixed | [20] |
| Administration costs booster dose | 14.50 | Fixed | [20] |
| Booster-dose boys invitation | 0.50 | Fixed | [20] |
| GP visit | 29 | Fixed | [17] |
| Microbiological diagnostics and MRI | 305 | Gamma (1;305) | [20], [53] |
| Full course of parenteral antibiotic treatment | 297 | Gamma (1;297) | [20] |
| Inpatient day (general ward) | 463 | Fixed | [17], [54] |
| Inpatient day (intensive care unit) | 2,263 | Fixed | [17] |
| Extra medical assistance with septic shock | 1,879 | Gamma (1;1879) | [20] |
| Treatment for scars | 506 | Gamma (1;506) | [20] |
| Treatment for amputations | 1,628 | Gamma (1;1628) | [20] |
| Institutional care (annual costs) | 90,036 | Gamma (1;90036)) | [17] |
| Special education (annual costs) | 4,700–13,810 | Gamma (age dependent) | [18], [22] |
| Pediatrician follow-up | 122 | Gamma (1;122) | [20] |
| Public health follow-up | 62 | Gamma (1;62) | [20] |
| Productivity costs (per hour) | |||
| Parents | 28.74 | Gamma (1;29) | [17], [18] |
| Children in the cohort | 9.51–37.34 | Gamma (age dependent) | [17] |
| Other parameters | |||
| Duration of hospitalization (days) | |||
| Standard hospitalization MD | 15 | Gamma (1;15) | [20] |
| Standard hospitalization MDS | 13 | Gamma (1;13) | [20] |
| Intensive care unit MDS | 5 | Gamma (1;5) | [20] |
| Treatment of scars | 2 | Gamma (1;2) | [20] |
| Treatment of amputations | 8 | Gamma (1;8) | [20] |
| Total drop in quality of life (QALY) | |||
| Amputations or scars | 0.17 | Beta (5.20;25.39) | [21] |
| Neurological sequelae | 0.25 | Beta (10.01;30.02) | [21] |
| Average quality of life general population | 0.89 | Beta (age dependent) | [55] |
| Discount rates (%) | |||
| Costs | 4.0 | Fixed | [17] |
| Health effects | 1.5 | Fixed | [17] |
HPV = human papillomavirus, GP = general practitioner, MD = meningococcal disease without septic shock, MDS = meningococcal disease with septic shock, MRI = magnetic resonance imaging scan, QALY = quality adjusted life year, NA = not applicable.