Table 3. Univariable logistic regression with treatment-related factors during chemotherapy as independent variables and oral mucositis as the outcome in all patients (n = 104).
| Variables | No oral mucositis | Oral mucositis | Univariable logistic regression | |
| n = 45 | n = 59 | OR (95% CI) | P-value | |
| n (%) | n (%) | |||
| Cytostatic regimen | ||||
| Methotrexate | 11 (24%) | 34 (58%) | 4.204 (1.790–9.872) | 0.001** |
| Doxorubicin | 27 (60%) | 24 (41%) | 0.457 (0.207–1.008) | 0.052 |
| Cytarabine | 10 (22%) | 18 (31%) | 1.537 (0.628–3.761) | 0.347 |
| Cyclophosphamide | 20 (44%) | 14 (24%) | 0.389 (0.168–0.901) | 0.028a |
| Actinomycin D | 11 (24%) | 2 (3%) | 0.108 (0.023–0.519) | 0.005a |
| Cisplatin | 19 (42%) | 4 (7%) | 0.100 (0.031–0.322) | <0.001a |
| Etoposide | 22 (49%) | 11 (19%) | 0.240 (0.100–0.576) | 0.001a |
| Hematological side effect | ||||
| Neutropenia (<0.5×109/l) | 33 (73%) | 48 (81%) | 1.587 (0.626–4.024) | 0.331 |
| Thrombocytopenia (<50×109/l) | 19 (42%) | 36 (61%) | 2.142 (0.972–4.718) | 0.059 |
| Lymphopenia (<1.0×109/l) | 28 (62%) | 48 (81%) | 2.649 (1.088–6.453) | 0.032* |
OR, odds ratio; CI, confidence interval.
a
Variables with OR <1 were not included in multivariable analysis since cytostatic regimens can only be considered as risk indicators for oral mucositis.
*
P<0.05,
**
P<0.01.