Table 3.
Soluble adhesion molecules in BAL fluid and sputum
| Controls | Smokers without COPD | Smokers with COPD | ||
|---|---|---|---|---|
|
BAL fluid |
ICAM-1 |
94.8 |
94.3 |
47.6*, § |
| (ng/mL) |
84.3-122.7 |
78.0-149.9 |
29.1-86.1 |
|
| ICAM-3 |
15.1 |
16.1 |
12.4 |
|
| (pg/mL) |
9.6-26.2 |
8.7-26.1 |
10.6-18.8 |
|
| PECAM-1 |
285.5 |
758.6§, |
351.4* |
|
| (pg/mL) |
194.2-684.1 |
525.7-1037.1 |
217.1-512.9 |
|
| VCAM-1 |
281.5 |
122.4 |
114.4 |
|
| (pg/mL) |
118.5-484.9 |
103.9-204.7 |
75.2-293.9 |
|
| Sputum supernatant (ng/mL) | ICAM-1 |
16.6 |
16.6 |
33.6 |
| <5.0-42.7 |
<5.0-34.4 |
<5.0-51.9 |
||
| ICAM-3 |
17.1 |
20.3 |
28.7 |
|
| 14.1-60.5 |
<11.0-43.2 |
10.3-49.3 |
||
| E-selectin |
< 4.0 |
< 4.0 |
12.5 |
|
| <4.0-17.7 |
<4.0-13.0 |
<4.0-23.1 |
||
| P-selectin |
< 19.0 |
< 19.0 |
< 19.0 |
|
| <19.0 - 40.9 |
< 19.0 -25.5 |
|||
| PECAM-1 |
12.2 |
9.0 |
13.4 |
|
| 6.6-23.8 |
< 4.0-13.8 |
< 4.0-18.0 |
||
| VCAM-1 | 7.1 |
< 5.0 |
8.5 |
|
| 5.1-7.8 | <5.0-8.7 | <5.0-12.0 | ||
Results are expressed as ng/mL; median and 25th- 75th percentiles.
§ p< 0.05 compared to non-smoking controls.
* p< 0.05 compared to smokers without COPD.