Figure 5. Changes in MAPK phosphorylation after a high-fat diet in wild-type and TLR4^−/− mice.

(A) Phosphorylation state of p38, JNK and ERK1/2 in skeletal muscle, liver and subcutaneous adipose tissue of wild-type (WT) and TLR4 knockout (TLR4^−/−) mice fed with a standard (chow) or a high-fat diet (HFD). Results are presented as means ± SEM (n = 8–10), * P<0.05, ** P<0.01, *** P<0.001. (B) Illustration of the data presented in panel A.